Co-Op Assignment Overview

Prime Medicine is seeking a co-op for the Spring 2025 semester with interest in large RNA molecules in-process analytics and purification to join the Process Chemistry team. The candidate will be involved in routine laboratory activities to support UV measurement, purification, sample analysis by UPLC & Mass instruments, and endotoxin testing of synthetic guide RNA. The candidate will learn a variety of in-process analytical techniques and understand oligonucleotide characterization quickly, will generate data and document them in the Prime’s project specific folder, and will share results in the weekly process chemistry team meeting. We want curious problem solvers who enjoy working on exciting projects, working within a team and are passionate about developing genetic editing technologies to better human health and well-being.

Primary Responsibilities:

• Supports characterization and purification of Prime’s long guide RNA (gRNA) using various laboratory techniques with purifiers, UPLC, LC-MS, Nano drop, Endotoxin etc.
• Integrate chromatograms for gRNA crude, fractions, final samples using Prime’s SOP to obtain the purity of the full-length product for the corresponding samples and tabulate data in the project specific folder
• Learn & contribute mass analysis for gRNA to identify MW for the full-length product and related impurities
• Assist senior level scientist for buffer preparation, maintenance of instruments, and to develop up to date analytical method that helps to increase in-process analytics capacity.
• Manage critical reagents for buffer preparation to support purification and analytics.

Required Qualifications:

• Must be enrolled in the undergraduate/advanced degree program at the time of Co-op program.
• Completed general chemistry lecture and lab prior to Spring 2025.
• Excellent written and oral communication skills, good organization skills, the ability to multi-tasks, and work as a team player and independently.
• A passion for learning and contributing to multiple facets of a program.

Preferred Qualifications:

• Prior relevant internship/Co-op experience is preferred.
• Completed analytical chemistry lecture and lab prior to Fall 2025 is preferred, but not required
• Familiarity working in chemistry laboratory, and experience with instrumentation such as UPLC, LC-MS, Nano drop, AKTA pure is a plus.

What We Offer:

• A cutting-edge team open to mentorship and networking.
• Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc.
• Participation in regular seminars with industry experts.
• Full participation in employee activities including learning and development offerings, social activities, etc.

NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.