Scheduled Hours

40

Position Summary

The Sah laboratory at Washington University School of Medicine in St. Louis (Department of Internal Medicine, Cardiology) and the Center for the Investigation of Membrane Excitability Disease (CIMED) studies the mechanisms of Transient Receptor Potential (TRP) and LRRC8a/ SWELL1 ion channel regulation and signal transduction. The laboratory uses electrophysiological (e.g., patch-clamp), imaging techniques, genetic mouse models (including CRISPR/cas9 technology), biochemical, and molecular approaches to investigate the regulation of signal transduction mechanisms of novel ion channels, including TRP/LRRC8 channels, in cardiac muscle, skeletal muscle, adipose tissue, and endothelium and pancreatic islet cells. 

Broadly speaking, the overarching goal of the Sah laboratory is to understand how ion channels and mechano-signaling influence cellular and organismal metabolism. We also combine medicinal chemistry with cryo-EM structure, molecular docking, and functional studies to guide synthesis of novel ion channel modulators for the treatment of human disease.

Job Description

Working Conditions

A laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment, provide standard care to research animals, and handle human biosamples.

Salary Range

Base pay is commensurate with experience.

Preferred Qualifications

• Strong background in cell biology and protein biochemistry with an interest in electrophysiology and ion channel biology.
• Working knowledge of computer software (Excel, Photoshop, and Prism) and general lab equipment.
• Demonstrated ability to work independently and communicate effectively.
• Troubleshooting skills.
• Ability to maintain complete and organized records.
• Effective verbal, written and interpersonal communication skills.

Required Qualifications

Bachelor’s degree. Candidates with additional education and experience are encouraged to apply.

Grade

00

Questions

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Accommodation

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Pre-Employment Screening

All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.

Benefits Statement

Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits.

EEO/AA Statement

Washington University in St. Louis is committed to the principles and practices of equal employment opportunity and especially encourages applications by those from underrepresented groups. It is the University’s policy to provide equal opportunity and access to persons in all job titles without regard to race, ethnicity, color, national origin, age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information.

Diversity Statement

Washington University is dedicated to building a diverse community of individuals who are committed to contributing to an inclusive environment – fostering respect for all and welcoming individuals from diverse backgrounds, experiences and perspectives. Individuals with a commitment to these values are encouraged to apply.