VP, Late-Stage Oncology Clinical Operations

Location: Gaithersburg, MD (US)

Join AstraZeneca to lead and modernize how late-stage oncology trials are designed, delivered, and scaled. We’re seeking a visionary VP to shape our Late Development Oncology Clinical Operations strategy and drive high-quality, tech-enabled execution across a portfolio that spans solid tumors and hematology. This is a mission-critical role with global reach, meaningful impact, and the backing to innovate.

What you’ll lead

• Portfolio-wide strategy and execution: Set direction and oversee clinical operations across late-stage oncology, ensuring trials deliver on time, to quality, and within budget.
• Enterprise-scale operations: Provide leadership for ~1,700 team members across 25 countries, including:
  • Program Management: ~100 team members
  • Study Management: ~200 team members
  • Site Management & Monitoring: ~1,400 team members
• Clinical excellence at scale: Drive study planning, feasibility, risk management, monitoring, and global patient recruitment—built on standardized, compliant, and continuously improving practices.
• Digital and AI acceleration: Champion adoption and optimization of AstraZeneca’s digital, data, and AI strategy in clinical operations to improve speed, quality, and patient impact.
• Cross-functional leadership: Partner with Oncology R&D, BioPharma R&D Clinical Operations, and the Oncology Business Unit. Your most senior reports are core members of Global Product Teams and play leadership roles on Clinical Project Teams.
• People, partners, and performance: Build a high-performing, future-ready organization; implement flexible outsourcing models; develop best-in-class processes and systems; and own clinical trial budgets and forecasting.

What you’ll bring

• Essential: Bachelor’s degree (or equivalent) in a scientific discipline; proven leadership of global clinical operations; deep oncology clinical operations expertise; strong line management; exceptional communication and influence; cross-boundary collaboration; ability to distill complex information; and functional leadership in resourcing and budget planning.
• Preferred: Master’s or PhD.

Why AstraZeneca

• Scale with agility: Lead one of the industry’s largest oncology operations while modernizing how we run trials.
• Impact patients faster: Advance therapies that change the standard of care in oncology.
• Innovate with purpose: Leverage digital, data, and AI to reimagine operational excellence and trial delivery.
• Develop extraordinary teams: Build capability and culture across a diverse, global organization.

If you’re a senior clinical operations leader from big pharma with a tech-forward, innovative mindset—and you’re ready to transform late-stage oncology delivery—apply to lead with us.

Pay Transparency: The annual base pay for this position ranges from $369,905 - $554,858 annual USD. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience.  In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Date Posted

22-Jan-2026

Closing Date

02-Feb-2026

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.