Posted:
10/6/2025, 7:59:04 AM
Location(s):
Little Rock, Arkansas, United States ⋅ Arkansas, United States
Experience Level(s):
Junior ⋅ Mid Level ⋅ Senior
Field(s):
Medical, Clinical & Veterinary
Closing Date:
Sponsorship Available:
The University of Arkansas for Medical Sciences (UAMS) has a unique combination of education, research, and clinical programs that encourages and supports teamwork and diversity. We champion being a collaborative health care organization, focused on improving patient care and the lives of Arkansans.
UAMS offers amazing benefits and perks (available for benefits eligible positions only):
Below you will find the details for the position including any supplementary documentation and questions you should review before applying for the opening. To apply for the position, please click the Apply link/button.
The University of Arkansas is an equal opportunity institution. The University does not discriminate in its education programs or activities (including in admission and employment) on the basis of any category or status protected by law, including age, race, color, national origin, disability, religion, protected veteran status, military service, genetic information, sex, sexual orientation, or pregnancy. Questions or concerns about the application of Title IX, which prohibits discrimination on the basis of sex, may be sent to the University’s Title IX Coordinator and to the U.S. Department of Education Office for Civil Rights.Persons must have proof of legal authority to work in the United States on the first day of employment.
All application information is subject to public disclosure under the Arkansas Freedom of Information Act.
For general application assistance or if you have questions about a job posting, please contact Human Resources at [email protected].
Department's Website:
Ph.D. in Bioscience, Biochemistry, Structural Biology, or a related PLUS five (5) years of laboratory experience in structural biology, including both X-ray crystallography and cryo-EM
Demonstrated expertise in “gene-to-structure” determination, including protein expression, purification, crystallization, and structure analysis
Proven record of successful cryo-EM structure determination supported by peer-reviewed publications or scientific presentations
Experience with bacterial protein expression and purification
Knowledge, Skills, and Abilities:
Proficiency with structural biology software such as RELION, CryoSPARC, Phenix, CCP4, and Coot
Strong understanding of protein biochemistry, molecular biology, and macromolecular structure-function relationships
Experience with Linux-based computational environments for data analysis and modeling
Ability to troubleshoot complex experimental and computational workflows
Excellent organizational, communication, and documentation skills
Demonstrated ability to work both independently and collaboratively in a multidisciplinary research setting
Commitment to maintaining safety, data integrity, and scientific rigor in all laboratory activities
Preferred Qualifications:
Experience expressing and purifying proteins using mammalian, yeast, or insect cell systems
Experience assisting and mentoring scientists in structure determination by cryo-EM and/or X-ray crystallography
Strong collaborative and problem-solving skills
This position is a Designated Research Position and involves scientific investigation or development that involves technologies, designs, or technical data considered sensitive enough to potentially impact national security and therefore requires strict controls on export or transfer to foreign entities. The Arkansas Research & Education Protection Act of 2025 requires the University to obtain additional information about your background for this Research Position.
Additional Information:
Responsibilities:
Conduct structural biology research using cryo-electron microscopy (cryo-EM) and X-ray crystallography.
Prepare and freeze grids, evaluate samples by negative stain and cryo-EM, and collect high-resolution cryo-EM data.
Perform particle selection, classification, and structure refinement to determine and finalize coordinate structures.
Conduct crystallization screening, crystal optimization, X-ray diffraction data collection, structure solution, and refinement.
Prepare and purify samples for analysis by cryo-EM and X-ray crystallography.
Train students, postdoctoral fellows, and scientists in structural biology techniques.
Supervise laboratory staff and ensure compliance with all University, State, and Federal safety regulations.
Maintain and operate laboratory equipment including FEI Vitrobot, Leica GP2, Mosquito crystallization robot, and Formulatrix plate hotel.
Manage inventory, order supplies, and track equipment service and maintenance schedules.
Supervise and support personnel in developing new laboratory protocols.
Collaborate with faculty, students, and postdoctoral fellows to advance research projects.
Work independently while maintaining consistent communication with the Principal Investigator.
Perform additional duties as assigned.
Salary Information:
Required Documents to Apply:
Optional Documents:
Recruitment Contact Information:
Please contact [email protected] for any recruiting related questions.
All application materials must be uploaded to the University of Arkansas System Career Site https://uasys.wd5.myworkdayjobs.com/UASYS
Please do not send to listed recruitment contact.
This position is subject to pre-employment screening (criminal background, drug testing, and/or education verification). A criminal conviction or arrest pending adjudication alone shall not disqualify an applicant except as provided by law. Any criminal history will be evaluated in relationship to job responsibilities and business necessity. The information obtained in these reports will be used in a confidential, non-discriminatory manner consistent with state and federal law.
Website: https://uamshealth.com/
Headquarter Location: Little Rock, Arkansas, United States
Employee Count: 10001+
Year Founded: 1879
IPO Status: Private
Last Funding Type: Grant
Industries: Education ⋅ Health Care ⋅ Non Profit