Fall 2026 Co-op: Quality Control

Co-Op Assignment Overview

Prime Medicine is seeking a co-op for the Fall 2026 semester with experience in biological and/or chemical techniques to join the Analytical Development and Quality Control (QC) team. The candidate will gain hands-on experience supporting analytical testing for gene therapy programs, including prime editing components, drug substances, and drug products.

This co-op will learn cutting-edge analytical technologies, develop an understanding of scientific and regulatory requirements for phase-appropriate analytical testing, and contribute to solving complex technical challenges related to prime editing programs. This is a unique opportunity to directly support the advancement of transformative genetic medicines toward the clinic.

We are looking for curious problem solvers who enjoy working collaboratively, thrive in a fast-paced environment, and are passionate about advancing genetic editing technologies to improve human health.

Primary Responsibilities

• Support product development sample analyses, in-process, release, and stability testing for LNP-based drug products, prime editing component RNAs, and cell-based drug products.
• Execute and support cell-based analytical activities.
• Perform cell-based potency, viability, conduct cell counting.
• Assist with optimization, troubleshooting, validation, and qualification of analytical methods.
• Participate in stability and reference standard programs including protocol/report preparation, data compilation, trending, and analysis.
• Assist with sample management and chain-of-custody documentation.
• Conduct clean room laboratory environmental monitoring for GMP manufacturing suites.
• Document and communicate experimental data in electronic notebooks and quality systems in accordance with cGMP requirements.
• Collaborate cross-functionally with Analytical Development, Manufacturing, MSAT, and Program Teams to support product and method development and qualification/validation.
• Contribute to laboratory functionality, safety compliance, and QC process optimization.
• Identify opportunities for assay optimization, workflow improvements, and automation.
• Demonstrate flexibility in supporting new projects, troubleshooting activities, and evolving program priorities.

Qualifications

• Currently enrolled in a B.S. or M.S. program in Biology, Biochemistry, Biotechnology, Bioengineering, Microbiology, Chemistry, Chemical Engineering, Pharmacology, or related field.
• Completion of foundational biology, biochemistry, microbiology, chemistry, and/or cell biology coursework with laboratory components.
• Experience with aseptic technique and basic cell culture is highly desirable, or liquid nanoparticle technology.
• Ability to work both independently and collaboratively.
• Self-motivated, detail-oriented, and organized with strong problem-solving skills.
• Excellent verbal and written communication skills.
• Eagerness to learn GLP/GMP practices and analytical methodologies.
• Comfortable engaging in cross-functional teamwork.
• Ability to manage multiple projects in a dynamic, fast-paced environment.

Preferred Qualifications

• Understanding of fundamental principles behind biological and chemical analytical techniques such as UV-Vis, HPLC/UPLC, LC-MS, PCR/qPCR/ddPCR, and potency assays.
• Hands-on experience with biological or chemical analytical techniques including sample preparation, dilution, extraction, and analysis.
• Experience with cell-based assays (e.g., viability assays, flow cytometry, functional assays).
• Familiarity with cell therapy or gene editing technologies.
• Prior internship or co-op experience in the biotechnology industry.

What We Offer

• A cutting-edge, collaborative team committed to mentorship and professional development.
• Exposure to gene and cell therapy analytical strategies in a GMP-regulated environment.
• Participation in seminars with industry experts.

Note: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.