Career Category

Scientific

Job Description

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Computational Biology - Principal Scientist

What you will do

Let’s do this. Let’s change the world. In this vital role you will analyze clinical biomarker data across a range of platforms, including but not limited to flow cytometry, immunoassays, transcriptomics, proteomics, spatial-omics, and other biomarker assays. This high-visibility role will contribute to advancing Amgen’s clinical programs and studies by integrating computational biology and bioinformatics techniques with biological and clinical data.

Key Responsibilities

• Develop clinical biomarker analysis plans to support evidence generation, precision medicine during clinical development of therapeutic molecules.

• Design and execute workflows for biomarker data analysis, integrating genomics, transcriptomics, proteomics, spatial and other omics modalities to support Amgen's early and late clinical development programs.

• Lead the analysis and interpretation of clinical biomarker data from various assay platforms, including flow cytometry, immunoassays, transcriptomics, proteomics, and spatial-omics.

• Design and implement computational algorithms to analyze multi-omics, multi-modal, and high-content data, with applications in target engagement evaluation, patient stratification, response prediction, indication selection, assay development, and diagnostic development.

• Work closely with clinical scientists and biomarker leads, to extract biological insights from high-dimensional datasets and integrate them into reverse translational research and clinical development plans.

• Collaborate cross-functionally with early development teams, biostatistics, clinical pharmacology, clinical biomarker leads, and research teams to manage data integration, analysis, and presentation.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a scientist with these qualifications.

Basic Qualifications:

• Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and 2 years of scientific research experience OR

• Master’s degree and 5 years of scientific research experience OR

• Bachelor’s degree and 7 years of scientific research experience

Preferred Qualifications:

• Proven expertise in analyzing multi-modal, multi-dimensional, and large-scale biological data.

• PhD, PharmD, or MD with 4 years of scientific research experience

• Hands-on experience in statistical modeling, machine learning, and AI applied to clinical biomarker data.

• Experience with analysis of spatial omics datasets

• Background in inflammation and/or rare diseases

• Proficiency in Python and R programming, with familiarity in various principles for data manipulation and visualization.

• Strong understanding of platforms used in clinical biomarker research, including flow cytometry, immunoassays, next-generation sequencing (NGS), and proteomics.

• Knowledge of immunology, autoimmune diseases, or oncology, and how computational biology can drive drug discovery in these areas.

• Excellent communication skills with the ability to present complex data analyses in multiple settings, including cross-functional team meetings, external collaborations, and scientific publications.

• Prior experience working in a matrixed biotech or pharmaceutical setting.

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts

• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan

• Stock-based long-term incentives

• Award-winning time-off plans

• Flexible work models, including remote and hybrid work arrangements, where possible

Apply now for a career that defies imagination

Objects in your future are closer than they appear. Join us.

careers.amgen.com

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.

Salary Range

163,221.00 USD - 189,182.00 USD