About Pioneering Medicines:

What if... We could harness the power of Flagship’s scientific platforms and create novel treatment options that benefit more patients, sooner?

Pioneering Medicines, a division of Flagship Pioneering, is building a world-class biopharmaceutical R&D capability focused on conceiving and developing life-changing treatments for patients by harnessing the power of Flagship's scientific platforms and applying those innovative approaches to serious diseases with unmet medical need. Unique to Pioneering Medicines’ approach is the opportunity to combine platforms to create truly novel and potentially transformative treatments. 

POSITION SUMMARY

Pioneering Medicines is seeking a curious and driven scientist with either basic science or clinical medicine (or both!) experience to imagine and create transformative therapies using Flagship’s broad array of novel platforms and technologies. Reporting to the Head of Explorations, this role focuses on leading new product concept explorations through an iterative hypothesis generation and refinement process.

The Associate will gather, review, and integrate information from multiple domains to advance product concept explorations. This involves consulting with external experts, shaping hypotheses, and presenting developed concepts to stakeholders. Other responsibilities include providing clinical insights on unmet needs and the patient journey, and contributing to clinical development plans, trial designs, and regulatory guidance.

Flagship Pioneering values an entrepreneurial spirit and seeks individuals comfortable working in a dynamic and cross-functional team environment. The level of this role will be commensurate with the candidate’s education and experience.

KEY RESPONSIBILITIES:

• Lead and contribute to high-impact product explorations across various therapeutic areas each year.
• Generate and refine transformative clinical outcomes, proposing scopes and objectives for each exploration.
• Collaborate with a small team to generate diverse product concepts, subjecting ideas to rigorous validation and expert critique.
• Define and articulate selected product concepts, detailing the platform capabilities and technologies required.
• Engage in the prioritization process of compelling concepts for development into ProtoCos.
• Build and maintain strong relationships across Flagship and its platform companies to understand their capabilities.
• Balance creative and unconstrained thinking with structured exploration methods designed to achieve transformational clinical outcomes.
• Foster a collaborative, high-energy team environment.

MINIMUM QUALIFICATIONS:

• Medical Degree (MD or DO or equivalent), PhD, or MD/PhD with significant research experience, including peer-reviewed publications.
• Basic scientific training and/or recognized scientific expertise in a relevant field.
• Clinical experience and clinical development experience are advantageous but not required.
• Highly resourceful and effective in uncertain circumstances.
• Strong prioritization and adaptive synthesis skills.
• Comfortable venturing into new scientific and clinical spaces.
• Willingness to consider unconventional approaches to challenging problems.
• Proven ability to work collaboratively within and across functions and teams.
• Leadership skills to guide teams through complex explorations and influence team decisions.
• Excellent written and verbal communication skills, with good conflict resolution capabilities.
• Ability to distill and synthesize information for varied audiences.

VALUES AND BEHAVIORS:

• Entrepreneurial spirit and mission-oriented towards breakthrough therapies.
• Courage to take bold risks to advance novel treatments.
• Ability to motivate and encourage colleagues at all levels.
• Fostering a growth-oriented, high-energy environment.
• Holding oneself and others accountable for commitments.

WHAT WE OFFER:

• Impactful role in a company recognized for transformative contributions.
• Dynamic startup culture with inspiring colleagues and leaders.
• Support for groundbreaking advancements in healthcare and sustainability.
• Opportunities for professional growth in an innovative environment.
• Comprehensive employee benefits and rewards program.

Join Pioneering Medicines and be part of a mission-driven organization dedicated to advancing human health and sustainability through scientific innovation.

More About Flagship Pioneering:

We are creative optimists, and we would love for you to consider joining our team!  See all our open opportunities across Flagship Pioneering’s Ecosystem!

Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has applied a unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $34 billion in aggregate value. To date, Flagship is backed by more than $4.4 billion of aggregate capital commitments, of which over $1.9 billion has been deployed toward the founding and growth of its pioneering companies alongside more than $10 billion of follow-on investments from other institutions. The current Flagship ecosystem comprises 41 transformative companies, including:  Axcella Health (NASDAQ: AXLA), Denali Therapeutics (NASDAQ: DNLI), Evelo Biosciences (NASDAQ: EVLO),  Foghorn Therapeutics, Indigo Ag, Kaleido Biosciences (NASDAQ: KLDO), Moderna (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Sana Biotechnology, Seres Therapeutics (NASDAQ: MCRB), and Syros Pharmaceuticals (NASDAQ: SYRS).

Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has applied a unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $34 billion in aggregate value. To date, Flagship is backed by more than $4.4 billion of aggregate capital commitments, of which over $1.9 billion has been deployed toward the founding and growth of its pioneering companies alongside more than $10 billion of follow-on investments from other institutions. The current Flagship ecosystem comprises 41 transformative companies, including:  Axcella Health (NASDAQ: AXLA), Denali Therapeutics (NASDAQ: DNLI), Evelo Biosciences (NASDAQ: EVLO),  Foghorn Therapeutics, Indigo Ag, Kaleido Biosciences (NASDAQ: KLDO), Moderna (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Sana Biotechnology, Seres Therapeutics (NASDAQ: MCRB), and Syros Pharmaceuticals (NASDAQ: SYRS).