Scientist – Peptide Chemistry

Location: Cambridge, UK

Salary: Competitive + Excellent Employee Benefits!

Introduction to the role:

AstraZeneca is a science-led, global biopharmaceutical company, with a focused portfolio in core therapies. At AstraZeneca we turn ideas into life changing medicines. We are committed to improving the health and lives of people across the globe, through our research and development platform, and a growing late-stage pipeline. Working in over 100 countries, we have strength in emerging markets, and our medicines are used by millions of patients and clinicians worldwide. Working here means being results-oriented and working together to make the impossible a reality.

We are seeking a skilled and enthusiastic peptide chemist to join our dynamic Peptide Discovery team. Situated at the Discovery Centre in Cambridge, you will be part of a chemistry team developing the next generation of peptide medicines.  

About the role:

In this laboratory-based role, you will apply peptide chemistry knowledge to support our Early Discovery projects. We are looking for someone who has a good understanding and background in solid-phase synthesis to support delivery of our peptide portfolio. In this laboratory-based position, you will contribute to the design, synthesis, purification and analytical characterisation of peptides, working either independently or in close collaboration with other scientists.

This role requires a background in peptide chemistry, problem-solving skills and the ability to work in a fast-paced, collaborative environment. As part of a growing team, you will benefit from numerous personal and professional development opportunities at AstraZeneca.  

Key responsibilities:

• Conduct laboratory-based experimental work in peptide chemistry to support project and platform objectives within the Peptide Discovery team.
• Design and synthesize peptides using solid-phase peptide synthesis (SPPS) techniques, using both automated peptide synthesisers and manual methods.
• Cleavage of peptides from resin supports, purification by preparative HPLC and analysis using mass spectrometry techniques.
• Identify, troubleshoot and help resolve synthetic and analytical challenges.
• Document experimental work accurately and in a timely manner, maintaining appropriate records in line with company standards.
• Communicate results clearly through presentations, data summaries, reports and discussion with colleagues and project team members.
• Contribute to multi-disciplinary research and drug development and collaborate effectively within matrix teams, building productive working relationships.
• Maintain and develop scientific knowledge by keeping up to date with literature, methodologies and advances in peptide chemistry and related disciplines.