Job Title: Associate Director, Translational Data Science – Hematology R&D
Location: South San Francisco, California, United States
 

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.

Recognizing the importance of individualized flexibility, our ways of working allow employees to balance personal and work commitments while ensuring we continue to create a strong culture of collaboration and teamwork by engaging face-to-face in our offices 3 days a week. Our head office is purposely designed with collaboration in mind, providing space where teams can come together to strategize, brainstorm and connect on key projects. 

Our dedication to sustainability is also central to our culture and part of what makes AstraZeneca a great place to work. We know the health of people, the planet and our business are interconnected which is why we’re taking ambitious action to tackle some of the biggest challenges of our time, from climate change to access to healthcare and disease prevention. 

Introduction to Role:
 

AstraZeneca’s Translational Data Science, Haematology R&D team is seeking an Associate Director passionate about driving strategic insights from sophisticated clinical and molecular data to support our hematology therapeutic portfolio. This role is based at AstraZeneca’s South San Francisco site, and will anchor translational data initiatives across clinical programs, as well as contribute to evidence generation advises forms clinical decision-making and accelerates patient impact.

As an individual contributor you will be a hands-on data science expert, responsible for developing reproducible analytical methods and data products. You will apply domain knowledge in hematology, clinical trial data standards, and modern analytical frameworks to enable robust interpretation and communication of translational results.
 

You will work at the intersection of clinical development, biomarkers, biostatistics and data engineering, collaborating across functions to improve the quality, accessibility and scientific utility of translational and clinical datasets, and you will mentor junior colleagues.
 

Accountabilities:

• Lead the design, implementation and validation of analytical workflows for translational and clinical trial data to generate actionable insights for hematology indications.
• Apply expertise in clinical data domains (including but not limited to ADaM and SDTM formats) to support data readiness for statistical analysis, regulatory deliverables and clinical reporting.
• Develop and maintain reproducible data transformation pipelines, quality-controlled datasets, and visualization tools that support cross-functional decision making.
• Collaborate with clinical operations, biostatistics, biomarker science and data engineering partners for decision support and to harmonize data standards and improve data interoperability.
• Interpret sophisticated data outputs and contribute to strategic planning, clinical study reports, regulatory documents and scientific communications.
• Mentor junior data scientists and analysts; provide technical guidance and promote adoption of standard processes in translational analytics.
• Serve as a subject matter expert and resource for hematology translational data analytics, with the ability to clearly communicate findings to scientific and clinical audiences.

Essential Skills/Experience:

• Advanced degree (PhD or equivalent) in a quantitative field (Biostatistics, Bioinformatics, Data Science, Computational Biology, or similar).
• 6+ years of proven experience in translational data science, clinical analytics or related data roles within biopharma (Master’s Degree: 8+ years of experience).
• Demonstrable expertise working with clinical trial datasets, with strong familiarity with clinical data standards such as ADaM and SDTM to support both analysis and regulatory submission readiness in drug development programs.
• Prior hands-on experience with large or complex clinical datasets from hematologic malignancies, including the ability to interpret clinical endpoints (MRD), laboratory data and disease-specific biomarkers.
• Strong programming skills in languages/tools such as R, Python and SAS and experience with scalable data workflows.
• Demonstrated experience in the application of innovativeS AI/ML methods for the analysis and interpretation of high-dimensional pre-clinical and clinical datasets.
• Demonstrated experience or strong understanding of GCP-compliant practices for data analysis, including the application of version control (Git), audit trails, and standardized documentation in environments such as Python and R/RStudio.
• Experience mentoring data scientists and enabling team-wide growth in analytics capabilities.
• Excellent written and verbal communication skills with a track record of effectively conveying complex scientific analyses to diverse audiences.
  Preferred:
• Involvement in regulatory data packages and interactions with health authorities.
• Track record of high-impact publications and/or open-source contributions in computational biology, AI, or oncology.
   

Where can I find out more?

• Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/
• Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/
• Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en
• Our US Footprint: Powering Scientific Innovation - YouTube

Total Rewards:
 

The annual base pay (or hourly rate of compensation) for this position ranges from $175,498 to $263,247 . Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.

AstraZeneca is an equal opportunity employer that is committed to diversity and inclusion and providing a workplace that is free from discrimination. AstraZeneca is committed to accommodating persons with disabilities. Such accommodation is available on request in respect of all aspects of the recruitment, assessment and selection process and may be requested by emailing [email protected].

#LI-Hybrid

Date Posted

23-Feb-2026

Closing Date

06-Mar-2026

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.