Job Title: Senior Clinical Data Manager II

Introduction to role:

Accountabilities:

• Study Data Leadership: Own the end-to-end Clinical Data Management (CDM) plan and delivery for assigned clinical studies, serving as the primary point of contact for all CDM matters at study level.
  Vendor Oversight: Direct and guide CDM vendors (CRO or in-house), providing clear expectations, supervision to Lead Data Managers, and ensuring delivery against scope, timelines and quality metrics.
• Risk Management: Proactively identify data and operational risks, collaborate with vendors to implement mitigations, and increase issues promptly to maintain study momentum.
• Standards and Consistency: Drive adherence to company data capture standards across indications and programs to ensure consistency, interoperability and downstream analysis readiness.
• Operational Excellence: Oversee day-to-day CDM activities including CRF design input, database build and validation oversight, query management, reconciliation activities, and database lock preparation, ensuring inspection-ready datasets.
• Regulatory Readiness: Contribute to preparation and response for audits and inspections related to data management on assigned studies, ensuring complete and accurate Trial Master File documentation for CDM vendor activities.
• Cross-Functional Collaboration: Partner closely with statisticians, statistical programmers, clinical teams and patient safety to align on data requirements and ensure fit-for-purpose outputs for decision making.
• Performance Management: Track vendor targets, timelines and achievements; review performance versus plan, recommend course corrections, and verify billing accuracy with recommendations for invoice payment.
• Mentorship and Capability Building: Mentor junior CDM colleagues and model guidelines, encouraging an environment of continuous learning and process improvement.
• Business Continuity: Maintain process robustness and database integrity for assigned studies, contributing to CDM standards evolution and taking on ad-hoc initiatives aligned with experience.
• Governance and Training: Ensure required training is completed before task execution and uphold compliance with all applicable procedures and data governance expectations.

Essential Skills/Experience:

• University or college degree in life sciences, pharmacy, nursing, or a related field (or equivalent experience)
• Knowledge of CDM and experience in the biotech, pharmaceutical, or CRO environment
  Understanding of Good Clinical Data Management Practices (GCDMP) and relevant regulatory requirements
• Experience working with clinical databases, CDM systems, and electronic data capture (EDC) tools
• Familiarity with query management processes and reconciliation activities
• Ability to manage multiple projects and prioritize effectively to meet deadlines
• Strong written and verbal communication skills
• Experience working collaboratively in distributed team environments
• Strong organizational, analytical skills, and attention to detail
• Understanding of the clinical drug development process

Desirable Skills/Experience:

• Proven knowledge of the build, development, validation, and interoperability of clinical information systems.
• Proven capacity to collaborate effectively with external partners
• Understanding of database structures, programming languages, data standards (CDISC) and practices as they apply to CRF design, database development, data handling and reporting
• Knowledge of SQL or SAS software
• Experience leading clinical studies as Data Management Lead

Why AstraZeneca:

Call to Action:
Step into a role where your data leadership drives critical study outcomes and patient impact—share your CV to start the conversation today.

Date Posted

29-Jun-2026

Closing Date

04-Jul-2026

AstraZeneca embraces diversity and equality of opportunity.  We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.  We believe that the more inclusive we are, the better our work will be.  We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.  We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.