Are you ready to shape clinical development in neurology and bring transformative medicines to people living with devastating conditions? This is your opportunity to lead end-to-end clinical strategy for high-impact programs, guiding evidence generation that directly informs patient care and regulatory success!

You will join a collaborative, passionate team that values diverse perspectives and decisive leadership. From selecting indications and dose strategies to authoring protocols and representing programs at health authority meetings, you will set direction and deliver measurable outcomes. Do you thrive at the intersection of rigorous science and bold program execution?

Accountabilities:

• Clinical Strategy and Program Leadership: Define a clear clinical development strategy aligned to target product profile, unmet need, and scientific rationale; lead indication selection, dose strategy, and evidence plans across all phases to build a confident path to approval and patient impact.
• Protocol and Study Design: Author or guide clinical study protocols, amendments, IBs, and SAP inputs; ensure endpoints, eligibility, assessments, and operationalization are scientifically sound and feasible
• Medical Oversight of Trials: Provide medical monitoring, review eligibility, safety events, and dose modifications; chair study medical reviews; establish proactive risk mitigation to safeguard patients while maintaining study integrity.
• Data Interpretation and Reporting: Lead clinical data review, benefit–risk assessment, and interpretation; contribute to CSRs, manuscripts, abstracts, and scientific presentations; support transparent data disclosure in accordance with policies to elevate program credibility.
• Regulatory Interactions: Contribute to regulatory strategy and author medical sections of IND/CTA, briefing books, and NDA/BLA/MAA; represent the program in health authority meetings (e.g., FDA, EMA, PMDA)
• Safety and Pharmacovigilance: Partner with drug safety to monitor the safety profile, support signal detection and management, and contribute to RMPs, DSURs, and aggregate reports
• Cross-Functional Collaboration: Work closely with clinical operations, biostatistics, translational medicine, regulatory affairs, CMC, commercial, and market access to build integrated plans milestone delivery
• External Engagement: Build relationships with key opinion leaders, investigators, and consortia; contribute to advisory boards; support site engagement and feasibility
• Evidence Generation and Publications: Build publication plans, ensure scientific rigor, and communicate results at congresses and in peer-reviewed journals
• Ethics and Compliance: Uphold Good Clinical Practice (GCP), ICH, local regulations, and company SOPs; ensure ethical conduct and patient-centric decision-making

Essential Skills/Experience:

• MD or DO (or equivalent)
• Significant experience as a physician
• Extensive general medical knowledge
• Extensive experience in managing or designing clinical trials which require close monitoring

Desirable Skills/Experience:

• Board certification in a relevant specialty preferred

The annual base pay for this position ranges from $241,613,60 to $362,420.40.  Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.

When we put unexpected teams in the same room, we ignite bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Why AstraZeneca:

Here, work is driven by the real journeys of people living with rare and devastating diseases, and your decisions will contribute directly to therapies that matter. We pair the agility of a biotech mindset with the reach and resources of a global biopharma, empowering you with cutting-edge science, data, and collaboration tools. We value kindness alongside ambition, bringing diverse thinkers together to challenge conventions and build better solutions for patients. You will grow with peers and leaders who invest in your development and trust you to lead with integrity, inclusiveness, and scientific excellence.

Step into this Medical Director role to steer neurology programs that change lives and see your leadership turn rigorous science into real-world impact!

Date Posted

22-Jan-2026

Closing Date

29-Jun-2026

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.